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1. Fibroblasts constitute a highly heterogeneous cell population, with phenotypic classification primarily based on two major categories: cell extraction location and cellular function. 2. Research directions in fibroblast studies can be summarized into six core domains.
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Endothelial cells have emerged as a focal point of research across multiple fields, and they can be categorized into the following five research phenotypes: 1. Universal markers; 2. Phenotypes associated with functional states; 3. Tissue-specific phenotypes, where endothelial cells in different organs possess unique markers and functions; 4. Additionally, endothelial cells can secrete a variety of cytokines, chemokines, and extracellular matrix components, giving rise to a distinct 'secretory phenotype'; 5. Circulating endothelial cell (CEC) phenotype.