KHM-5M Human Thyroid Cancer Cells (undifferentiated)

Human undifferentiated thyroid cancer cells (ATC) can produce interleukin-8. It is from a 65-year-old male who suffered from tumors in the right anterior cervical region and supraclavicular region. It was identified as free of mycoplasma/STR and put into storage.

Animal species/Organism Human

Tissue and Cell Type thyroid; From pleural effusion

Morphology Fibroblast-like, adherent growth

Culture media and additives/Complete Growth Medium and Culture Conditions:

90% 1640 (MD0200)+10% fetal bovine serum (SD0200)+G/A (SD0038)

Complete medium: 1640 complete medium (article number: MD0201)

Gas phase: air, 95%; Carbon dioxide, 5%. Temperature: 37 ℃.

Freezing conditions: basic medium+5% DMSO+20% FBS (SD0200)

Complete cryopreservation solution: non-programmed cooling cell cryopreservation solution (low serum) (SD0001)

Note: This product is for scientific research only

PubMed=1728417

Yoshida M., Matsuzaki H., Sakata K., Takeya M., Kato K., Mizushima S., Kawakita M., Takatsuki K.

Neutrophil chemotactic factors produced by a cell line from thyroid carcinoma.

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PubMed=16924234; DOI=10.1038/sj.onc.1209899

Yu W., Imoto I., Inoue J., Onda M., Emi M., Inazawa J.

A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.

Oncogene 26:1178-1187(2007)

PubMed=23833040; DOI=10.1210/jc.2013-2383

Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.

Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.

J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953

Landa I., Pozdeyev N., Korch C., Marlow L.A., Smallridge R.C., Copland J.A., Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.

Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.

Clin. Cancer Res. 25:3141-3151(2019)