TC-1 Mouse Lung Epithelial Cells

This cell is a C57BL/C (H-2b) mouse lung epithelial cell co-transformed by HPV16E6, E7 and ras genes.

Species: Mice

Organizational source/Issue and Cell Type: Lung

Morphology: Epithelial like cell like, adherent growth

Culture media and additives/Complete Growth Medium and Culture Conditions:

90% 1640 (MD0200)+10% fetal bovine serum (SD0200)+G/A (SD0038)

Complete medium: 1640 complete medium (article number: MD0201)

Gas phase: air, 95%; Carbon dioxide, 5%. Temperature: 37 ℃.

Freezing conditions: basic medium+5% DMSO+20% FBS (SD0200)

Complete cryopreservation solution: non-programmed cooling cell cryopreservation solution (low serum) (SD0001)

Note: This product is for scientific research only

PubMed=8548765

Lin K.-Y., Guarnieri F.G., Staveley-O'Carroll K.F., Levitsky H.I., August J.T., Pardoll D.M., Wu T.-C.

Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

Cancer Res. 56:21-26(1996)

PubMed=12559790; DOI=10.1016/s0264-410x(02)00519-4

Smahel M., Sima P., Ludvikova V., Marinov I., Pokorna D., Vonka V.

Immunisation with modified HPV16 E7 genes against mouse oncogenic TC-1 cell sublines with downregulated expression of MHC class I molecules.

Vaccine 21:1125-1136(2003)

PubMed=31638243; DOI=10.3892/or.2019.7356

Lhotakova K., Grzelak A., Polakova I., Vackova J., Smahel M.

Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules.

Oncol. Rep. 42:2826-2835(2019)