PaTu 8988t [PaTu8988t] Human pancreatic cancer cells

PaTu 8988t was established in 1985 by a German research team, originating from liver metastases of pancreatic adenocarcinoma in a 64-year-old female patient. This cell line and its sister strain PaTu 8988s originate from the same tumor, but the two exhibit distinctly different degrees of differentiation and biological behavior. The PaTu 8988t cell line retains high differentiation features, exhibiting an epithelioid morphology. When tumor formation occurs in nude mice, tubular structures can form, resembling the histological features of primary pancreatic adenocarcinoma. PaTu 8988s cells differentiate less, grow solid, exhibit chaotic cell polarity, and possess stronger metastatic potential. By comparing with PaTu 8988s, differences in metastatic potential of pancreatic cancer with different differentiation states were studied. The high differentiation characteristics of PaTu 8988t make it an ideal model for studying the negative correlation between "degree of differentiation and transfer ability."

Animal Species: Human 

Tissue Source:Pancreatic cancer

Morphology:Epithelial cells, adherent growth

Culture Medium Formula:90% DMEM (MD0100)+5% fetal bovine serum (SD0200)+5% Equine Serum(SD0300)+G/A (SD0038)

Gas phase: Air, 95%; Carbon dioxide, 5%. Temperature: 37℃. 

Freezing conditions:  90% FBS (SD0200) + 10% DMSO

Complete cryopreservation solution: No Programmed Cryopreservation Cells Solution (low Serum)(SD0001)

Declaration: The product is for scientific research purposes only.

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