Primary Cell Immortalization

Primary Cells Have Become A Research Tool Favored By Researchers Day By Day Because They Can Imitate Human Metabolism. However, Primary Cells Used To Be Notoriously Difficult To Cultivate, Which Requires A Lot Of Time, Cost And Resources. Even Though Cells Have Survived The Extremely Rigorous Dissociation Steps, Pollution Is Still A Hidden Danger, Which May Make The Achievements Of Several Days Disappear. In Addition, There Are Other Problems Such As Cell Pollution, Slow Growth And Limited Number& Nbsp; Cell Lines Are The First Choice For Research Because They Are Easy To Culture And Have A Considerable Yield. However, They Are Not Perfect. Cell Lines Mutate Constantly. Successive Generations Lead To Changes In Their Genotype And Phenotype. Sometimes, They Have Become Beyond Recognition. A Research Team Once Found That The Cells Generated By Adenovirus Transformation Of HEK293 Cell Line Were Closer To Immature Neurons Than Human Embryonic Kidney Cells. So Immortalized Cells From HTERT, PSC And IPSC Came Into Being. They Are Not Real Primary Cells, But They Can Express The Characteristics That Most Primary Cells Should Have. For Example, Forced Expression Of HTERT Allows Primary Cells To Maintain Sufficient Telomere Length And Avoid Proliferative Aging. HTERT Induced Primary Cells Not Only Had The Ability Of Continuous Passage, But Also Had No Chromosome Instability. This Kind Of Cells Can Be Expanded, Frozen, Preserved And Thawed To Adapt To The Experimental Schedule, But It Only Delays The Aging Of Cells And Increases The Number Of Generations, Which Does Not Mean That Cells Can "live Forever" Like Hela. PSC Is The Same As IPSC. The Real Value Of PSC Is That It Can Differentiate From One Cell Into Multiple Cell Types. IPSC Allows Researchers To Collect Easily Obtained Cells And Transform Them Into Hard To Obtain Cells. However, The Results Of Pre Experiment And Validation Experiment Generally Recommend Using Primary Cells, Because Cells Without Any Modification Can Obtain The Most Accurate Data For The Experiment. ACCEGEN Provides A Series Of Immortalized Spot Cells And Immortalized Technical Services. The Spot Immortalized Cells Include Immortalized Cells Of Alveolar Epithelium, Immortalized Neural Stem Cells, And Immortalized Liver Cells& Nbsp; The Characteristics Of ACCEGEN's Scientific Research Service: All Scientific Research Problems Are Solved In One Stop; Fast Turnaround Time And One-to-one Service High Quality And Professional Technical Support Save You Time And Money