Pituitary Tumor Cells Of MMQ Rats

This cell is derived from rat pituitary tumor and secretes prolactin; Expression of functional dopamine receptor. The cell could not form tumor in immunosuppressed mice, but could form clone in semi-solid medium.


Organizational source/Issue and Cell Type: Pituitary gland
Morphology: Epithelial like, suspended growth

Culture media and additives/Complete Growth Medium and Culture Conditions:

90% F12K (MD0400)+10% fetal bovine serum (SD0200)+G/A (SD0038)

Complete medium:F12K complete medium (article number: MD0401)

Gas phase: air, 95%; Carbon dioxide, 5%. Temperature: 37 ℃.

Freezing conditions: basic medium+5% DMSO+20% FBS (SD0200)

Complete cryopreservation solution: non-programmed cooling cell cryopreservation solution (low serum) (SD0001)

Note: This product is for scientific research only

PubMed=2844508; DOI=10.1210/endo-123-5-2341

Judd A.M., Login I.S., Kovacs K., Ross P.C., Spangelo B.L., Jarvis W.D., MacLeod R.M.

Characterization of the MMQ cell, a prolactin-secreting clonal cell line that is responsive to dopamine.

Endocrinology 123:2341-2350(1988)

Patent=US5510260

MacLeod R.M., MacQueen M.V., Login I.S.

Prolactin secreting cell line and method of obtaining the same.

Patent number US5510260, 23-Apr-1996

PubMed=15541569; DOI=10.1016/j.mce.2004.07.018

Ooi G.T., Tawadros N., Escalona R.M.

Pituitary cell lines and their endocrine applications.

Mol. Cell. Endocrinol. 228:1-21(2004)