RPMI 1846 Syrian hamster melanoma cells

This cell line comes from melanoma in Syrian hamsters. This cell line can continuously produce melanin in vitro and can be used for melanin synthesis research. However, it is uncertain whether it can permanently produce melanin.

Animal Species:Syrian hamster

Tissue Source:Skin

Morphology:Epithelial cells; Grows close to the wall

Culture Medium Formula: McCoy's 5A Complete Medium（MD0901）

Gas phase: Air, 95%; Carbon dioxide, 5%. Temperature: 37℃. 

Freezing conditions:  90% FBS (SD0200) + 10% DMSO

Complete cryopreservation solution: No Programmed Cryopreservation Cells Solution (low Serum)(SD0001)

Declaration: The product is for scientific research purposes only.

PubMed=14475649; DOI=10.1126/science.137.3534.986
George Eugene Moore, Donald F. Lehner, Yasumoto Kikuchi, Louise Ann Less;
Continuous culture of a melanotic cell line from the golden hamster.
Science 137:986-987(1962)

PubMed=14071829; DOI=10.1093/jnci/31.5.1217
George Eugene Moore, David Mount, G. Tara, N. Schwartz;
Culture of malignant tumors of the Syrian hamster.
J. Natl. Cancer Inst. 31:1217-1237(1963)

PubMed=5682441; DOI=10.1002/ijc.2910030405
Kay Ulrich, George L. Tritsch, George Eugene Moore;
Tyrosine utilization by pigmented hamster melanoma cells cultured in vitro.
Int. J. Cancer 3:446-453(1968)

DOI=10.1007/BF02618370
Cyril S. Stulberg, Lewis Lemon Coriell, Alexis John Kniazeff, John E. Shannon;
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=5556532; DOI=10.1111/1523-1747.ep12292072
George Lipkin;
Pigment transformation and induction in hamster malignant amelanotic melanocytes. An effect of nucleic acids from hamster benign blue nevus.
J. Invest. Dermatol. 57:49-65(1971)

PubMed=4522794; DOI=10.1073/pnas.71.3.849; PMCID=PMC388112
George Lipkin, Margarete E. Knecht;
A diffusible factor restoring contact inhibition of growth to malignant melanocytes.
Proc. Natl. Acad. Sci. U.S.A. 71:849-853(1974)

PubMed=3734481; DOI=10.1111/1523-1747.ep12524360
George Lipkin, Martin J. Rosenberg, Vera Klaus-Kovtun;
Contact inhibitory factor also restores anchorage and serum dependence to hamster melanoma cells.
J. Invest. Dermatol. 87:305-308(1986)

PubMed=1319723; DOI=10.1016/0898-6568(92)90083-k
Darryl Scott Pickering, Lennard Polycarp Niles;
Expression of nanomolar-affinity binding sites for melatonin in Syrian hamster RPMI 1846 melanoma cells.
Cell. Signal. 4:201-207(1992)