Panc02 [Panc-02; Pan02] Mouse pancreatic cancer cells

The Panc02 cell line is a mouse pancreatic ductal adenocarcinoma (PDAC) cell line, originally established by Corbett et al. by implanting cotton thread containing 3-methylcholanthrene into the pancreas of C57BL/6 mice induced in pancreatic tumors. By mixing Panc02 cells with cryogenic Matrigel and injecting them into the tail of the pancreas in C57BL/6 mice, an in situ model simulating the pathological features of human pancreatic cancer can be established. This cell line is also widely used to study the biological characteristics of pancreatic cancer, immunotherapy, drug screening, and the tumor microenvironment.

Animal Species: Mouse

Tissue Source:Pancreatic ducts, adenocarcinoma

Morphology:Epithelial cells, adherent growth

Culture Medium Formula:RPMI-1640 Complete Medium（MD0206）

Gas phase: Air, 95%; Carbon dioxide, 5%. Temperature: 37℃. 

Freezing conditions:  90% FBS (SD0200) + 10% DMSO

Complete cryopreservation solution: No Programmed Cryopreservation Cells Solution (low Serum)(SD0001)

Declaration: The product is for scientific research purposes only.

PubMed=6692374
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PubMed=11558631; DOI=10.1385/IJGC:29:1:37
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A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy.
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PubMed=20805420; DOI=10.4049/jimmunol.0902609; PMCID=PMC3693576
Jennifer Lynn Gnerlich, Jonathan Bower Mitchem, Joshua S. Weir, Narendra V. Sankpal, Hiroyuki Kashiwagi, Brian A. Belt, Matthew Ryan Porembka, John M. Herndon, Timothy J. Eberlein, Simon Peter Goedegebuure, David C. Linehan;
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J. Immunol. 185:4063-4071(2010)

PubMed=21720167; DOI=10.1159/000329413
Lars Ivo Partecke, Matthias Sendler, Andre Kaeding, Frank Urlich Weiss, Julia V. Mayerle, Annegret Dummer, Trung Dung Nguyen, Nele Albers, Sven Speerforck, Markus M. Lerch, Claus-Dieter Heidecke, Wolfram von Bernstorff, Albrecht Stier;
A syngeneic orthotopic murine model of pancreatic adenocarcinoma in the C57/BL6 mouse using the Panc02 and 6606PDA cell lines.
Eur. Surg. Res. 47:98-107(2011)

PubMed=22208613; DOI=10.2174/156652412799218868; PMCID=PMC3799885
Yi Wang, Yu-Qing Zhang, Jing-Xuan Yang, Xiao-Ling Ni, Shi-He Liu, Zhao-Shen Li, Sally E. Hodges, William E. Fisher, Francis Charles Brunicardi, Richard Alexander Gibbs, Marie-Claude Gingras, Min Li;
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Curr. Mol. Med. 12:331-341(2012)

PubMed=24278292; DOI=10.1371/journal.pone.0080580; PMCID=PMC3835415
Maria P. Torres, Satyanarayana Rachagani, Joshua J. Souchek, Kavita Mallya, Sonny L. Johansson, Surinder Kumar Batra;
Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: applications in diagnosis and therapy.
PLoS ONE 8:e80580.1-e80580.12(2013)