Sharing Good Things: The Magical Effect Of Lidocaine.

How Can The Extracted Macrophages Not Be Digested? With Lidocaine And EDTA To Numb It, The Cells Will Surrender. This Is Really A Good Thing. After Checking, It Can Be Used Flexibly And Properly, And It Has Many Benefits. What Is Lidocaine? It Is A Local Anesthetic Sodium Channel Blocker, With Membrane Stabilizing Effect, And Is Used For Anti Ventricular Arrhythmia; It Also Has The Regulating Function Of The Immune System, And Plays An Anti-inflammatory Role In Many Aspects Of Inflammatory Reaction. It Significantly Inhibits Inflammatory Reaction, Acute Lung Injury, Anti-cancer Drug Sensitization Effect, And Bacteriostasis. It Is Often Used Clinically For Brain Protection And Reducing Postoperative Cognitive Dysfunction (POCD)& Nbsp; Antiarrhythmic Effect Of Lidocaine: Lidocaine Selectively Acts On Purkinje Fiber Cells And Ventricular Muscle Cells Because Of Class IB Antiarrhythmic Drugs. The Anesthetic Effect Slows Down The 4-phase Division Rate, Reduces The Autonomy Of Purkinje Fibers, Promotes K+outflow, Shortens The Action Potential Duration, And Relatively Prolongs The Effective Refractory Period. It Is Commonly Used For The Prevention And Treatment Of Ventricular Arrhythmia. Lidocaine Can Slow Down Cardiac Conduction Function, Inhibit Cardiac Contractility And Reduce Cardiac Output. Lidocaine Has Been Used For A Long Time And Has More Experience In Clinical Antiarrhythmia. Clinicians Often Choose Lidocaine To Control Ventricular Arrhythmias, And Its Effectiveness And Safety Are High  Lidocaine Can Prevent Excessive Inflammatory Reaction: Many Studies Have Shown That Lidocaine Has A Good Role In Preventing And Treating Inflammation Induced By Trauma Or Endotoxin. Lidocaine Is A Membrane Stabilizer, Which Can Inhibit The Adhesion And Aggregation Of Neutrophils (PMN), Reduce The Release Of Oxygen Free Radicals And Proteolytic Enzymes, Stabilize Cell Membranes, Regulate Cytokines, And Inhibit Excessive Inflammation. Inflammatory Mediator LB4, Interleukin-1 α （IL-１ α） They Are Strong PMN Chemoattractants, Which Can Induce PMN To Edge, Thresh, Exude, Generate Superoxide, And Increase Vascular Permeability Together With Prostaglandin E2. In Vitro Incubation Of Monocytes With Lidocaine Of Different Concentrations (2-20mol/L) Can Significantly Inhibit LB4 And IL-1 α The Micromolar Concentration Level Of Lidocaine Can Inhibit The Release Of Histamine From Leukocytes, Mast Cells And Basophils, Which Indicates That Lidocaine Can Inhibit The Release Of Some Key Inflammatory Mediators And Play An Anti-inflammatory Role. Therefore, Most Serum Free Freezers Will Contain This Substance To Reduce Cell Infiltration And Promote Cells To Enter Dormancy As Soon As Possible& Nbsp; In Clinical Application, Many Studies Have Found That Intravenous Infusion Of Lidocaine During Operation Can Regulate The Immune Function Of Patients And Speed Up Their Postoperative Recovery. There Are Complications Such As Phlebitis During PCIA. Adding Lidocaine To The Intravenous Analgesia Pump Can Effectively Prevent The Occurrence Of Phlebitis. Perioperative Low-dose Intravenous Injection Of Lidocaine Can Reduce The Inflammatory Reaction Caused By Surgery, Reduce A Commonly Used Amide Local Anesthetic During Surgery. Studies Have Shown That It Has Anti-inflammatory Effect, And Perioperative Intravenous Infusion Of Lidocaine Can Reduce Postoperative Pain, Reduce The Use Of Opioid Analgesics, Reduce The Inflammatory Reaction Of The Body, Accelerate The Recovery Of Gastrointestinal Function And Shorten The Hospital Stay Of Patients& Nbsp; The Antibacterial Effect Of Lidocaine Has Been Reported That Lidocaine Can Inhibit The Adhesion And Chemotaxis Of Granulocytes And Inhibit Bacteria In Cells. Studies Have Shown That Local Anesthetics Inhibit The Growth Of Escherichia Coli Cells, And Cause The Outflow Of Cell Contents And Interfere With Their Respiration. To Sum Up The Above Reports, It Is Safe And Feasible To Prevent Microorganisms From Growing In The Epidural Space And Catheter When Lidocaine Is Used For Epidural Anesthesia Or Long Postoperative Analgesia. The Mechanism Of Antibacterial Activity Of Local Anesthetics Such As Lidocaine Is Still Unclear. It Is Possible That The Interaction Between Local Anesthetics And Macromolecular Substances Or Cell Membranes On The Surface Of Bacterial Cells Interferes With Eukaryotic And Prokaryotic Cell Membranes, Changes The Function Of Cell Membranes, And Causes Bacterial Death Or Growth Inhibition. Studies Have Shown That Under The Commonly Used Clinical Dosage (0.5%~1.0% Lidocaine And 0.125%~0.25% Bupivacaine), There Is A Significant Bacteriostatic Effect, And The Bacteriostatic Effect Tends To Increase With The Increase Of Concentration. It Can Be Considered That 1% Lidocaine Has Stronger Antibacterial Effect Than 0.125% Bupivacaine& Nbsp; Lidocaine Can Easily Pass Through The Blood-brain Barrier And Has A Membrane Stabilizing Effect. Lidocaine Can Directly Contract The Brain And Large Blood Vessels Of The Whole Body. At The Same Time, It May Block Na+, K+, Ca2+channels, Reduce Intracellular Na+, Ca2+concentrations, Reduce ATP Consumption, Protect Hypoxic Neurons, Reduce K+outflow, Inhibit The Release Of Excitatory Amino Acids And Oxygen Free Radicals, Reduce Brain Tissue Damage, Improve Cerebral Blood Flow, And Play A Role In Brain Protection. Studies Have Shown That Lidocaine Can Not Only Directly Contract The Brain And Large Blood Vessels Of The Whole Body, But Also Expand The Cerebral Microvessels At The Trauma Site, Reduce Cerebral Oxygen Metabolism, Reduce Anaerobic Digestion, Maintain Blood Glucose Stability, And Do Not Prolong The Recovery Time After Surgery.