Mouse Immortalized Dendritic Cell Line (MutuDC1940)

Background: As Messengers Bringing The Internal And Adaptive Immune System, The Conventional Issue Resident DC (cDC) Acts As Sentinels In Secondary Lymphoid Organizations And Other Issues For Antigen Capture And Presentation The Wild-type MutuDC1940 Cell Line Is An Immortalised Splenic CD8& Alpha;+  Subset (CD11chigh,B220-,DEC205+,CD24high,CD11b-) Of Conventional Dendritic Cells Derived From The CD11c:SV40LgT Transgenic Mice.  The MutuDC1940 Cell Line Retains Response To TLR Ligands Such As CpG (TLR9-L) And PolyIC (TLR3-L) And To A Lesser Extent LPS (TLR4-L) Stimulation By Up-regulation Of Co-stimulatory Molecules CD40, CD80 And CD86.  In Addition To Responding To PAMP Stimulation And Producing Th1 Cytokines Such As IL-12, These Cells Are Also Capable Of Presenting Antigen In The Context Of Both MHC-I And MHC-II, Including Direct Antigen Presentation And Cross Presentation Of Cell Associated Antigens, Traditional Tissue Resident DCs (cDCs) Serve As Sentinels For Antigen Capture And Presentation In Secondary Lymphoid Organs And Other Tissues. The Wild Type MutuDC1940 Cell Line Is An Immortal Spleen Cd8 From The Traditional Dendritic Cells Of CD11c: SV40LgT Transgenic Mice; Alpha+subgroups (CD11chigh, B220 -, DEC205+, CD24high, CD11b -). MutuDC1940 Cell Line Retained The Response To The Stimulation Of TLR Ligands Such As CpG (TLR9-L), PolyIC (TLR3-L) And LPS (TLR4-L) By Up Regulating Costimulatory Molecules CD40, CD80 And CD86. In Addition To Reacting To PAMP Stimulation And Producing Th1 Cytokines Such As IL-12, These Cells Can Also Present Antigens In MHC-I And MHC-II Environments, Including Direct Antigen Presentation And Cross Presentation Of Cell Related Antigens. Animal Species/Oganism  Mouse Tissue Source; Tissue And Cell Type  Dendritic Cell Morphology; Neurocyte Like, Adherent Growth & Nbsp; Note: This Product Is Only For Scientific Research