Human Bronchial Epithelial Cell Line (BEAS-2B)

Background: BEAS-2B Cells Were Derived From Normal Bronchial Ephelium Obtained From Autopsy Of Non Cancerous Individuals Cells Were Infected With A Replication-defective SV40/adenovirus 12 Hybrid And Cloned.  Squamous Differentiation Can Be Observed In Response To Serum.  This Ability Can Be Used For Screening Chemical And Biological Agents Inducing Or Affecting Differentiation And/or Carcinogenesis.  The Cell Line Has Been Applied For Studies Of Pneumococcal Infection Mechanisms.  BEAS-2B Was Described To Express Keratins And SV40 T Antigen.  Subculturing The Cells Before Fluency Is Necessary As Fluent Cultures Rapidly Under Malignant Terminal Differentiation. BEAS-2B Cells Come From Normal Bronchial Epithelium, Which Comes From Autopsy Of Non Cancerous Individuals. The Cells Were Infected And Cloned By Replication Defective SV40/adenovirus 12 Hybrid. Squamous Differentiation Was Observed In Serum. This Capability Can Be Used To Screen Chemical And Biological Agents That Induce Or Affect Differentiation And/or Carcinogenesis. This Cell Line Has Been Used To Study The Mechanism Of Pneumococcal Infection. BEAS-2B Expressed Keratin And Sv40t Antigen. Cell Passage Before Fusion Is Necessary Because Squamous Terminal Differentiation Occurs Rapidly In Fusion Culture. Animal Species/Oganism & Nbsp; People Organization Source; Tissue And Cell Type  Bronchial Morphology; Epithelial Cell Like, Adherent Growth& Nbsp; Note: This Product Is Only For Scientific Research