Endothelial Cells And ACE2 Receptors

In The Spring Of 2003, Severe Acute Respiratory Syndrome (SARS) Broke Out In China. Studies Found That The Coronavirus (SARS CoV) That Caused SARS Invaded The Cells Through The Combination Of The Spike Glycoprotein (S Protein) On Its Surface And Angiotensin Converting Enzyme 2 (ACE2) In Human Respiratory Epithelial Cells. Therefore, ACE2 Was Identified As A Receptor For SARS CoV [1]. In December 2019, An Outbreak Of Novel Coronavirus (2019 NCoV) Infection Occurred In Wuhan, Hubei Province, Followed By A Rapid Outbreak Worldwide. Research Shows That 2019 NCoV Infects The Human Body Through The Combination Of Echinocandin On The Surface Of The Virus And ACE2 Of The Host Respiratory Epithelial Cells. Therefore, ACE2 Has Also Been Confirmed As The Receptor Of 2019 NCoV. What Is ACE2? It Is The Receptor Of SARS CoV; Also: The Receptor Of 2019 NCoV Is Also A Key Molecule To Maintain The Balance Of Renin Angiotensin System (RAS), Which Can Better Protect Blood Vessels. The Article From The Lancet Also Pointed Out That The Relationship Between ACE2 Receptor And 2019 NCoV, In Addition To Causing Respiratory Diseases, Cardiovascular Complications Are Rapidly Becoming The Main Threat Of Coronary Virus Disease (COVID-19) In 2019. However, The Mechanism Of The Disproportionate Impact Of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Infection On Patients With Cardiovascular Comorbidities Is Not Completely Clear. SARS CoV-2 Infects The Host Through The Angiotensin Converting Enzyme 2 (ACE2) Receptor, Which Is Expressed In Multiple Organs Including The Lung, Heart, Kidney And Intestine. Endothelial Cells Also Express ACE2 Receptors. At Present, It Is Unclear Whether The Vascular Disorder Of COVID-19 Is Caused By The Involvement Of Viruses In Endothelial Cells. Interestingly, SARS CoV-2 Can Directly Infect Human Vascular Organs In Vitro. It Was Pointed Out That In A Series Of Patients With COVID-19, Endothelial Cells Involved Vascular Beds In Different Organs. We Found That The Accumulation Of Inflammatory Cells Was Related To Endothelial Cells& Nbsp; Cell Systems Has A Large Number Of Endothelial Cells For Research. The Main Feature Of Our Cells Is That They Do Not Carry Any Antibodies And Have No Antibody Interference. This Is A More Biologically Relevant Tool And A More Effective Way To Enhance Scientific Research.