MAPT R406W HOM Of Neural Stem Cells Derived From Human Ipsc

Background: Human IPSC Derived Neural Stem Cells That Have Been Generally Edited Using CRISPR-Cas9 Technology To Introduce The R406W Mutation (CGG& Gt; TGG) Into The MAPT Gene This Line Is Homozygous For The R406W Mutation So Both Alleles Contain The Mutation.& Nbsp; The R406W Mutation In MAPT Has Been Implicated In Familial Frontotemporal Dementia And Parkinsonism (Hutton Et Al., 1998; Behnam Et Al., 2015) And Has Been Seen In Patients With Clinical Presentation Resembling Alzheimer' S Disease (Rademakers Et Al., 2003; Lindquist Et Al., 2008).  The R406W Mutation Reduces The Ability Of MAPT/tau To Bind To Microtubules In Vitro (Hong Et Al., 1998).& Nbsp; Animal Species/Oganism & Nbsp; People Organization Source; Tissue And Cell Type  Morphology Of Neural Stem Cells; Wall Attached Growth; Note: This Product Is Only For Scientific Research