Human Ipsc Derived Neural Stem Cells LRRK2 G2019S HOM

Background: Human IPSC Derived Neural Stem Cells That Have Been Generally Edited Using CRISPR-Cas9 Technology To Introduce The G2019S Mutation (GGC> AGC) In The LRRK2 Gene This Line Is Homozygous For The G2019S Mutation So Both Alleles Contain The Mutation.The G2019S Mutation In LRRK2 Has Been Implicated In Autosomal-dominant Familial Parkinson' S Disease With Late Onset (Fonzo Et Al., 2006, Thaler Et Al., 2009).  The G2019S Mutation Increases The Kinase Activity Of LRRK2 Causing Increased Autophosphorylation And Substrate Phosphorylation That May Affect Neuronal Cell Health In Parkinson' S Disease Patients (West Et Al., 2005).& Nbsp; We Used CRISPR-Cas9 Technology To Edit The Gene Of Neural Stem Cells Derived From Human Ipsc, And Introduced G2019S Mutation (ggc> AGC) In LRRK2 Gene. This Line Is Homozygous For The G2019S Mutation, So Both Alleles Contain Mutations. The G2019S Mutation In LRRK2 Is Associated With Autosomal Dominant Familial Late Onset Parkinson's Disease (Fonzo Et Al., 2006, Thaler Et Al., 2009). The G2019S Mutation Increases The Kinase Activity Of LRRK2, Leading To An Increase In Autophosphorylation And Substrate Phosphorylation, Which May Affect The Health Of Nerve Cells In Patients With Parkinson's Disease (West Et Al., 2005). Animal Species/Oganism & Nbsp; People Organization Source; Tissue And Cell Type  Morphology Of Neural Stem Cells; Wall Attached Growth; Note: This Product Is Only For Scientific Research