Mouse Immortalized Kupffer Cell Line (ImKC)

Background: Immortalised Mouse Kupffer Cells (ImKC) Are Isolated From Male H-2Kb-tsA58 Transient Mice Which Expresses The Thermal Tank TsA58 Of SV40 40 Large T Antigen And Were Sorted Through Identifying The F4/80 Marker The Immortalised Cells Expresses P53 Levels With Increases Telomerase Activity And Retains The Some Functional Features Compared To The Primary Cells.  ImKC Cells Can Propagate Without The Presence Of IFNy At 37°C, And Are Able To Produce Proinflammatory Cytokines When Induced With Lipopolysaccharide (LPS).  These Cells Are Valuable For Studies In Proinflammatory Cytokines (TNF- α,  IL-6 And IL-1 β)  And Their Roles In Kuppfer Cells, In Processes In Life Injury, And For Research In Chronic Diseases. Compared With Primary Cells, Immortalized Cells Express P53 Levels, Increase Telomerase Activity, And Retain Some Functional Characteristics. In The Absence Of IFNy, ImKC Cells Can Proliferate At 37c And Produce Proinflammatory Cytokines Induced By Lipopolysaccharide (LPS). These Cells Are Valuable For The Study Of Proinflammatory Cytokines (TNF - TNF, IL-6 And IL-1 Cytokines) And Their Roles In Kuppfer Cells, In The Process Of Liver Injury, And In The Study Of Chronic Diseases. Animal Species/Oganism & Nbsp; Mouse Tissue Source; Tissue And Cell Type  Kuppfer Cell Morphology; Wall Attached Growth& Nbsp; Note: This Product Is Only For Scientific Research